Protein name:
Mitogen-activated protein kinase kinase kinase 7 ;
Alternative:
Transforming growth factor-beta-activated kinase 1 (TGF-beta-activated kinase 1) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2. Identified in the TRIKA2 complex composed of MAP3K7, TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2. Interacts with PPM1L. Interaction with PP2A and PPP6C leads to its repressed activity. Interacts with TRAF6 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with TAOK1 and TAOK2; interaction with TAOK2 interferEs with MAP3K7 interaction with IKKA, thus preventing NF-kappa-B activation. Interacts with WDR34 (via WD domains). Interacts with RBCK1. Interacts with TGFBR1; induces MAP3K7 activation by TRAF6 (By similarity). Interacts with CYLD. Interacts with MAPK8IP1 and VRK2.
Function:
Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B.
Subcellular Location:
N/A
Protein Attributes:
50:
MSTASAASSS | SSSSASEMIE | APSQVLNFEE | IDYKEIEVEE | VVGRGAFGVV |
100:
CKAKWRAKDV | AIKQIESESE | RKAFIVELRQ | LSRVNHPNIV | KLYGACLNPV |
150:
CLVMEYAEGG | SLYNVLHGAE | PLPYYTAAHA | MSWCLQCSQG | VAYLHSMQPK |
200:
ALIHRDLKPP | NLLLVAGGTV | LKICDFGTAC | DIQTHMTNNK | GSAAWMAPEV |
250:
FEGSNYSEKC | DVFSWGIILW | EVITRRKPFD | EIGGPAFRIM | WAVHNGTRPP |
300:
LIKNLPKPIE | SLMTRCWSKD | PSQRPSMEEI | VKIMTHLMRY | FPGADEPLQY |
350:
PCQYSDEGQS | NSATSTGSFM | DIASTNTSNK | SDTNMEQVPA | TNDTIKRLES |
400:
KLLKNQAKQQ | SESGRLSLGA | SRGSSVESLP | PTSEGKRMSA | DMSEIEARIV |
450:
ATAGNGQPRR | RSIQDLTVTG | TEPGQVSSRS | SSPSVRMITT | SGPTSEKPAR |
500:
SHPWTPDDST | DTNGSDNSIP | MAYLTLDHQL | QPLAPCPNSK | ESMAVFEQHC |
550:
KMAQEYMKVQ | TEIALLLQRK | QELVAELDQD | EKDQQNTSRL | VQEHKKLLDE |
579:
NKSLSTYYQQ | CKKQLEVIRS | QQQKRQGTS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Rat
Human
Mouse
ELISA Kit for Mouse Mitogen-activated protein kinase kinase kinase 7
ELISA Kit for Mouse Mitogen-activated protein kinase kinase kinase 7
ELISA Kit for Mouse Mitogen-activated protein kinase kinase kinase 7
ELISA Kit for Mouse Mitogen-activated protein kinase kinase kinase 7
CLIA Kit for Mouse Mitogen-activated protein kinase kinase kinase 7
CLIA Kit for Mouse Mitogen-activated protein kinase kinase kinase 7
CLIA Kit for Mouse Mitogen-activated protein kinase kinase kinase 7
CLIA Kit for Mouse Mitogen-activated protein kinase kinase kinase 7
Polyclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 7
Polyclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 7
Polyclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 7
Polyclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 7
Monoclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 7
Monoclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 7
Monoclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 7
Monoclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 7
Protein for Mouse Mitogen-activated protein kinase kinase kinase 7
Protein for Mouse Mitogen-activated protein kinase kinase kinase 7
Protein for Mouse Mitogen-activated protein kinase kinase kinase 7
Protein for Mouse Mitogen-activated protein kinase kinase kinase 7
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH SMAD6
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PPM1L
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;UBIQUITINATION;PROTEASOMAL DEGRADATION
5.
"Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses."
Reiley W.W.
,
Jin W.
,
Lee A.J.
,
Wright A.
,
Wu X.
,
Tewalt E.F.
,
Leonard T.O.
,
Norbury C.C.
,
Fitzpatrick L.
,
Zhang M.
,
Sun S.C.
J. Exp. Med.204:1475-1485(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION;INTERACTION WITH CYLD;DEUBIQUITINATION BY CYLD
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH VRK2 AND MAPK8IP1
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON ENZYME REGULATION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389 AND SER-412;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON ENZYME REGULATION;REVIEW ON FUNCTION